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KMID : 0387720120230010072
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Korean Journal of Blood Transfusion
2012 Volume.23 No. 1 p.72 ~ p.77
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Development of Severe Hemolytic Anemia after Treatment with Anti-D Immunoglobulin in a Patient with Immune Thrombocytopenic Purpura
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Jung Bo-Kyeung
Kim Jang-Su
Yun Seung-Gyu
Ko Sun-Young
Cho Chi-Hyun
Lim Chae-Seung
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Abstract
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A 78-year-old female was admitted due to nasal bleeding and purpuric macules on both legs. The patient underwent renal biopsy, and a diagnosis of Henoch-Schonlein purpura nephritis was made. The patient’s platelet count was 1.6×1010/L, and, based on results from bone marrow biopsy, the patient was diagnosed with immune thrombocytopenic purpura. Despite treatment with glucocorticoid and IV immunoglobulin, thrombocytopenia continued. The patient’s blood group was Rhesus D positive and treatment with IV anti-D immunoglobulin followed. Thereafter, platelet count showed a rapid increase; however, occurrence of hemolytic anemia, hyperbilirubinemia, and hemoglobinuria consistent with intravascular hemolysis was observed.
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KEYWORD
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Anti-D immunoglobulin, Immune thrombocytopenic purpura, Hemolytic anemia
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